{"product_id":"ctcf-antibody-sc-f0373","title":"CTCF Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eThe DNA-binding protein CCCTC-binding factor (CTCF) plays a crucial role in generating topologically associating domains (TADs), which are pivotal for gene regulation and recombination during development and disease. CTCF acts to block loop extruding cohesin in a DNA tension-dependent manner, leading to loop extrusion direction switching and loop shrinkage.\u003c\/p\u003e\u003cp\u003eReported cellular context includes centromere, chromosome, and nucleus, which can matter when signal is compared across treatments or changing cell states. Following CTCF across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eCTCF is commonly interpreted in the context of developmental biology research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans centromere, chromosome, and nucleus, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between centromere, chromosome, and nucleus across matched conditions\u003c\/li\u003e\n\u003cli\u003estage-dependent patterns during differentiation, morphogenesis, or lineage commitment\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003cli\u003etime-matched comparisons so changes reflect biology rather than handling or sampling drift\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for CTCF. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in CTCF reflect biology rather than handling. When interpreting CTCF, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep CTCF trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577447915865,"sku":"F0373-20UL","price":149.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577447948633,"sku":"F0373-100UL","price":359.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577447981401,"sku":"F0373-2X100UL","price":539.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F0373-IHC1.jpg?v=1773598391","url":"https:\/\/absource.de\/products\/ctcf-antibody-sc-f0373","provider":"Absource Diagnostics","version":"1.0","type":"link"}