{"product_id":"dactolisib-bez235-s1009","title":"Dactolisib (BEZ235)","description":"\u003cp\u003e\u003cstrong\u003eDactolisib (BEZ235)\u003c\/strong\u003e is an inhibitor of PI3K and ATR and related targets used in studies of PI3K-Akt-mTOR Signaling and DNA Damage Response and related signaling programs. In practice, this places the compound in experiments that measure growth-factor signaling, survival control, and nutrient-sensing outputs and checkpoint activation, DNA repair, and genome-stability control in autophagy, cancer, and cell signaling models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting PI3K and ATR and related targets, Dactolisib (BEZ235) can be used to examine growth-factor signaling, survival control, and nutrient-sensing outputs and checkpoint activation, DNA repair, and genome-stability control. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In autophagy, cancer, and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving PI3K and ATR and related targets\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to PI3K-Akt-mTOR Signaling and DNA Damage Response and related signaling programs\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eBiochemical kinase assays, phospho-signaling studies, and selectivity profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Dactolisib (BEZ235) is appropriate when a defined chemical perturbant is needed to connect PI3K and ATR and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in autophagy, cancer, and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"50 mg","offer_id":57805167886681,"sku":"S1009-50MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"200 mg","offer_id":57805167919449,"sku":"S1009-200MG","price":303.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57805167952217,"sku":"S1009-1G","price":953.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/BEZ235-NVP-BEZ235-chemical-structure-S1009.gif?v=1776172723","url":"https:\/\/absource.de\/products\/dactolisib-bez235-s1009","provider":"Absource Diagnostics","version":"1.0","type":"link"}