{"product_id":"danirixin-gsk1325756-s6620","title":"Danirixin (GSK1325756)","description":"\u003cp\u003e\u003cstrong\u003eDanirixin (GSK1325756)\u003c\/strong\u003e is an antagonist of CXCR and Interleukins used in studies of JAK-STAT Signaling and Immune Signaling and related signaling programs. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to cytokine-responsive transcriptional signaling and immune regulation and cytokine-mediated signaling and inflammatory effector responses in immunology and inflammation models.\u003c\/p\u003e\n\n\u003cp\u003eBy blocking CXCR and Interleukins, Danirixin (GSK1325756) can be used to examine cytokine-responsive transcriptional signaling and immune regulation and cytokine-mediated signaling and inflammatory effector responses. The gpcr annotation adds relevance to GPCR pharmacology, ligand-binding, and signaling assays, together with downstream-response mapping in the same experimental setting. In immunology and inflammation models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving CXCR and Interleukins\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to JAK-STAT Signaling and Immune Signaling and related signaling programs\u003c\/li\u003e\n\u003cli\u003eReceptor-blockade and ligand-competition studies\u003c\/li\u003e\n\u003cli\u003eGPCR pharmacology, ligand-binding, and signaling assays\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Danirixin (GSK1325756) is appropriate when a defined chemical perturbant is needed to connect CXCR and Interleukins with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in immunology and inflammation models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"1 mg","offer_id":57809400365401,"sku":"S6620-1MG","price":164.0,"currency_code":"EUR","in_stock":true},{"title":"5 mg","offer_id":57809400398169,"sku":"S6620-5MG","price":419.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57809400430937,"sku":"S6620-1ML\/DMSO","price":488.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/gsk1325756-chemical-structure-s6620.gif?v=1776200191","url":"https:\/\/absource.de\/products\/danirixin-gsk1325756-s6620","provider":"Absource Diagnostics","version":"1.0","type":"link"}