{"product_id":"dclk1-antibody-sc-f1388","title":"DCLK1 \/ DCAMKL1 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eDCLK1 \/ DCAMKL1 (Doublecortin-like kinase 1) is a microtubule-associated protein with a C-terminal serine\/threonine kinase domain, originally identified in the developing brain and known for its role in microtubule polymerization and neuronal migration. Structurally, Dclk1 contains two N-terminal doublecortin (DCX) domains for microtubule binding, a central serine\/proline-rich domain involved in protein-protein interactions, and a C-terminal CaMKI-like kinase domain that undergoes autophosphorylation. Depending on the literature source, DCLK1 may also be discussed as DCLK1 \/ DCAMKL1 and CL1.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cytoplasm and synapse, which can matter when signal is compared across treatments or changing cell states. Following DCLK1 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eDCLK1 is commonly interpreted in the context of cancer, neuroscience, and developmental biology research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cytoplasm and synapse, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cytoplasm and synapse across matched conditions\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003ecompartment-specific patterns relevant to neuronal polarity, transport, or synaptic context\u003c\/li\u003e\n\u003cli\u003estage-dependent patterns during differentiation, morphogenesis, or lineage commitment\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for DCLK1. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in DCLK1 reflect biology rather than handling. When interpreting DCLK1, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep DCLK1 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577716810073,"sku":"F1388-20UL","price":169.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577716842841,"sku":"F1388-100UL","price":379.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577716875609,"sku":"F1388-2X100UL","price":569.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F1388-wb.gif?v=1773599681","url":"https:\/\/absource.de\/products\/dclk1-antibody-sc-f1388","provider":"Absource Diagnostics","version":"1.0","type":"link"}