{"product_id":"dlk1-antibody-sc-f2757","title":"DLK-1 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eDelta-like 1 homolog (DLK1) is a transmembrane protein belonging to the Notch\/EGF-like family, encoded by the DLK1 gene within the imprinted DLK1-DIO3 gene cluster. DLK1 features an extracellular domain (ECD) with six EGF-like repeats, a transmembrane region, and a short intracellular domain (ICD). The ECD can be cleaved by the enzyme ADAM17, releasing soluble fragments that function in paracrine signalling. Depending on the literature source, DLK1 may also be discussed as DLK-1.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cytoplasm and membrane, which can matter when signal is compared across treatments or changing cell states. Following DLK1 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eDLK1 is commonly interpreted in the context of developmental biology and cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cytoplasm and membrane, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cytoplasm and membrane across matched conditions\u003c\/li\u003e\n\u003cli\u003estage-dependent patterns during differentiation, morphogenesis, or lineage commitment\u003c\/li\u003e\n\u003cli\u003esignal-dependent shifts after ligand, inhibitor, or growth-factor perturbation\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for DLK1. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in DLK1 reflect biology rather than handling. When interpreting DLK1, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep DLK1 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577970008409,"sku":"F2757-20UL","price":169.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577970041177,"sku":"F2757-100UL","price":399.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577970073945,"sku":"F2757-2X100UL","price":599.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F2757-wb.gif?v=1773600667","url":"https:\/\/absource.de\/products\/dlk1-antibody-sc-f2757","provider":"Absource Diagnostics","version":"1.0","type":"link"}