{"product_id":"doxorubicin-e2516","title":"Doxorubicin","description":"\u003cp\u003e\u003cstrong\u003eDoxorubicin\u003c\/strong\u003e is a substrate of Topoisomerase used in studies of DNA Damage Response and Apoptosis. It is especially relevant in apoptosis, cancer, and dna damage \/ repair models, where defined compound exposure can be linked to checkpoint activation, DNA repair, and genome-stability control and caspase-associated cell-death signaling and survival decisions.\u003c\/p\u003e\n\n\u003cp\u003eAs a substrate linked to Topoisomerase, Doxorubicin can be used to examine checkpoint activation, DNA repair, and genome-stability control and caspase-associated cell-death signaling and survival decisions. The enzyme annotation adds relevance to enzyme-activity assays, substrate-conversion studies, and mechanism profiling, together with downstream-response mapping in the same experimental setting. In apoptosis, cancer, and dna damage \/ repair models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving Topoisomerase\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to DNA Damage Response and Apoptosis\u003c\/li\u003e\n\u003cli\u003eKinetic, turnover, and substrate-competition experiments\u003c\/li\u003e\n\u003cli\u003eEnzyme-activity assays, substrate-conversion studies, and mechanism profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Doxorubicin is appropriate when a defined chemical perturbant is needed to connect Topoisomerase with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, cancer, and dna damage \/ repair models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57804594315609,"sku":"E2516-5MG","price":193.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57804594348377,"sku":"E2516-25MG","price":488.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57804594381145,"sku":"E2516-100MG","price":979.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57804594413913,"sku":"E2516-1G","price":2918.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57804594446681,"sku":"E2516-1ML\/DMSO","price":244.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/e2516-adriamycin-chemical-structure.gif?v=1776167748","url":"https:\/\/absource.de\/products\/doxorubicin-e2516","provider":"Absource Diagnostics","version":"1.0","type":"link"}