{"product_id":"ephb4-antibody-sc-f1330","title":"EphB4 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eEphB4, or Ephrin type-B receptor 4, is a receptor tyrosine kinase (RTK) encoded by the EPHB4 gene, belonging to the Eph family of RTKs, which are crucial for various developmental processes, including nervous system and vascular development. EphB4 interacts with its ligand ephrinB2 to regulate cellular repulsion and adhesion, playing a key role in cardiovascular formation, neuronal guidance, and endothelial cell growth during embryogenesis and adulthood. Depending on the literature source, EPHB4 may also be discussed as Eph receptor B4\/HTK.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cell membrane, which can matter when signal is compared across treatments or changing cell states. Following EPHB4 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eEPHB4 is commonly interpreted in the context of cancer, neuroscience, and cardiovascular research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cell membrane, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003esignal enrichment within cell membrane relative to the broader cellular background\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003ecompartment-specific patterns relevant to neuronal polarity, transport, or synaptic context\u003c\/li\u003e\n\u003cli\u003echanges linked to vascular, contractile, or hemodynamic cell-state cues\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for EPHB4. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in EPHB4 reflect biology rather than handling. When interpreting EPHB4, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep EPHB4 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577691447641,"sku":"F1330-20UL","price":159.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577691480409,"sku":"F1330-100UL","price":339.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577691513177,"sku":"F1330-2X100UL","price":499.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F1330-IF.png?v=1773599598","url":"https:\/\/absource.de\/products\/ephb4-antibody-sc-f1330","provider":"Absource Diagnostics","version":"1.0","type":"link"}