{"product_id":"erralpha-antibody-sc-f1190","title":"Estrogen Related Receptorα Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eERRALPHA is a target of interest in many antibody-based workflows. Estrogen-related receptors (ERRs) are a subfamily of nuclear receptors that includes three members: ERRα, ERRβ, and ERRγ. ERRα has a ligand-independent transcription activation domain at the N-terminal, a DNA-binding domain (DBD) with two zinc fingers in the centre that facilitate interaction with specific DNA motifs, and a C-terminal domain responsible for ligand-dependent transcription. Depending on the literature source, ERRALPHA may also be discussed as Estrogen Related Receptoralpha and Estrogen Related Receptor alpha.\u003c\/p\u003e\u003cp\u003eReported cellular context includes nucleus and cytoplasm, which can matter when signal is compared across treatments or changing cell states. Following ERRALPHA across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eERRALPHA is commonly interpreted in the context of cancer, metabolism, and cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans nucleus and cytoplasm, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between nucleus and cytoplasm across matched conditions\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003eresponses linked to nutrient status, mitochondrial state, or metabolic rewiring\u003c\/li\u003e\n\u003cli\u003esignal-dependent shifts after ligand, inhibitor, or growth-factor perturbation\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for ERRALPHA. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in ERRALPHA reflect biology rather than handling. When interpreting ERRALPHA, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep ERRALPHA trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577644720473,"sku":"F1190-20UL","price":149.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577644753241,"sku":"F1190-100UL","price":329.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577644786009,"sku":"F1190-2X100UL","price":489.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F1190-wb.gif?v=1773599408","url":"https:\/\/absource.de\/products\/erralpha-antibody-sc-f1190","provider":"Absource Diagnostics","version":"1.0","type":"link"}