{"product_id":"etrasimod-apd334-e2363","title":"Etrasimod (APD334)","description":"\u003cp\u003e\u003cstrong\u003eEtrasimod (APD334)\u003c\/strong\u003e is an antagonist of S1P Receptors used in studies of GPCR Signaling. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to receptor-driven second-messenger signaling and desensitization dynamics in immunology and inflammation models.\u003c\/p\u003e\n\n\u003cp\u003eBy blocking S1P Receptors, Etrasimod (APD334) can be used to examine receptor-driven second-messenger signaling and desensitization dynamics. The gpcr annotation adds relevance to GPCR pharmacology, ligand-binding, and signaling assays, together with downstream-response mapping in the same experimental setting. In immunology and inflammation models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving S1P Receptors\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to GPCR Signaling\u003c\/li\u003e\n\u003cli\u003eReceptor-blockade and ligand-competition studies\u003c\/li\u003e\n\u003cli\u003eGPCR pharmacology, ligand-binding, and signaling assays\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Etrasimod (APD334) is appropriate when a defined chemical perturbant is needed to connect S1P Receptors with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in immunology and inflammation models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57804575310169,"sku":"E2363-5MG","price":173.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57804575342937,"sku":"E2363-25MG","price":488.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57804575375705,"sku":"E2363-100MG","price":1248.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/E2363-Etrasimod-APD334-chemical-structure.png?v=1776167647","url":"https:\/\/absource.de\/products\/etrasimod-apd334-e2363","provider":"Absource Diagnostics","version":"1.0","type":"link"}