{"product_id":"fancd2-antibody-sc-f1154","title":"FANCD2 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eFanconi anemia group D2 protein (FANCD2) is a highly conserved gene that plays a crucial role in the Fanconi anemia (FA) signalling pathway, essential for DNA damage repair and genome stability. When activated, typically during DNA replication or in response to DNA damage, FANCD2 undergoes monoubiquitination and interacts with various FA and non-FA proteins to repair DNA crosslinks.\u003c\/p\u003e\u003cp\u003eReported cellular context includes nucleus, which can matter when signal is compared across treatments or changing cell states. Following FANCD2 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eFANCD2 is commonly interpreted in the context of metabolism and dna damage \/ repair research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans nucleus, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003esignal enrichment within nucleus relative to the broader cellular background\u003c\/li\u003e\n\u003cli\u003eresponses linked to nutrient status, mitochondrial state, or metabolic rewiring\u003c\/li\u003e\n\u003cli\u003estress-induced changes after checkpoint activation or genotoxic challenge\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for FANCD2. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in FANCD2 reflect biology rather than handling. When interpreting FANCD2, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep FANCD2 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577630564697,"sku":"F1154-20UL","price":149.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577630597465,"sku":"F1154-100UL","price":329.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577630630233,"sku":"F1154-2X100UL","price":489.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F1154-IF.png?v=1773599363","url":"https:\/\/absource.de\/products\/fancd2-antibody-sc-f1154","provider":"Absource Diagnostics","version":"1.0","type":"link"}