{"product_id":"fh-antibody-sc-f0888","title":"Fumarase Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eFumarase, also known as fumarate hydratase (FH), is a critical enzyme involved in the tricarboxylic acid (TCA) cycle within the mitochondrial matrix. It also has a conserved cytosolic isoenzyme across species, from yeast to humans. The mitochondrial form participates in cellular respiration, while the cytosolic form plays a role in the cellular response to DNA double-strand breaks (DSBs). Depending on the literature source, FH may also be discussed as Fumarase.\u003c\/p\u003e\u003cp\u003eReported cellular context includes chromosome, cytoplasm, mitochondrion, and nucleus, which can matter when signal is compared across treatments or changing cell states. Following FH across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eFH is commonly interpreted in the context of cancer and metabolism research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans chromosome, cytoplasm, and mitochondrion, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between chromosome, cytoplasm, and mitochondrion across matched conditions\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003eresponses linked to nutrient status, mitochondrial state, or metabolic rewiring\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for FH. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in FH reflect biology rather than handling. When interpreting FH, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep FH trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577552609625,"sku":"F0888-20UL","price":149.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577552642393,"sku":"F0888-100UL","price":329.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577552675161,"sku":"F0888-2X100UL","price":489.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F0888-wb.gif?v=1773599057","url":"https:\/\/absource.de\/products\/fh-antibody-sc-f0888","provider":"Absource Diagnostics","version":"1.0","type":"link"}