{"product_id":"fkbp12-antibody-sc-f3489","title":"FKBP12 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eFKBP12 is a cytosolic protein belonging to the immunophilin family, ubiquitously expressed in all tissues and functions primarily as a peptidyl-prolyl cis\/trans isomerase (PPIase), facilitating protein folding and acting as a molecular chaperone. Structurally, FKBP12 contains a single PPIase domain with a compact globular fold and a hydrophobic pocket that binds natural substrates and immunosuppressive drugs such as FK506 and rapamycin. Depending on the literature source, FKBP12 may also be discussed as Peptidyl-prolyl cis-trans isomerase FKBP1A and PPIase FKBP1A.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cytoplasm, membrane, and sarcoplasmicreticulum, which can matter when signal is compared across treatments or changing cell states. Following FKBP12 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state. In practice, this target is often considered at the family or isoform-group level, so experimental interpretation benefits from matched controls and clear comparison logic.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eFKBP12 is commonly interpreted in the context of immunology and cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cytoplasm, membrane, and sarcoplasmicreticulum, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cytoplasm, membrane, and sarcoplasmicreticulum across matched conditions\u003c\/li\u003e\n\u003cli\u003econtext differences tied to immune-cell state, activation, or lineage composition\u003c\/li\u003e\n\u003cli\u003esignal-dependent shifts after ligand, inhibitor, or growth-factor perturbation\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for FKBP12. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in FKBP12 reflect biology rather than handling. When interpreting FKBP12, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep FKBP12 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57578027188569,"sku":"F3489-20UL","price":169.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57578027221337,"sku":"F3489-100UL","price":369.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57578027254105,"sku":"F3489-2X100UL","price":549.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F3489-IF.png?v=1773601261","url":"https:\/\/absource.de\/products\/fkbp12-antibody-sc-f3489","provider":"Absource Diagnostics","version":"1.0","type":"link"}