{"product_id":"fulvestrant-ici-182780-s1191","title":"Fulvestrant (ICI-182780)","description":"\u003cp\u003e\u003cstrong\u003eFulvestrant (ICI-182780)\u003c\/strong\u003e is an antagonist of Estrogen Receptor and Estrogen\/Progesterone Receptors used in studies of Apoptosis and Autophagy and related signaling programs. In practice, this places the compound in experiments that measure caspase-associated cell-death signaling and survival decisions and autophagic flux, lysosomal turnover, and stress adaptation in apoptosis, autophagy, and cancer models.\u003c\/p\u003e\n\n\u003cp\u003eBy blocking Estrogen Receptor and Estrogen\/Progesterone Receptors, Fulvestrant (ICI-182780) can be used to examine caspase-associated cell-death signaling and survival decisions and autophagic flux, lysosomal turnover, and stress adaptation. The nuclear receptor annotation adds relevance to reporter-gene, receptor-binding, and transcriptional assays, together with downstream-response mapping in the same experimental setting. In apoptosis, autophagy, and cancer models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving Estrogen Receptor and Estrogen\/Progesterone Receptors\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to Apoptosis and Autophagy and related signaling programs\u003c\/li\u003e\n\u003cli\u003eReceptor-blockade and ligand-competition studies\u003c\/li\u003e\n\u003cli\u003eReporter-gene, receptor-binding, and transcriptional assays\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Fulvestrant (ICI-182780) is appropriate when a defined chemical perturbant is needed to connect Estrogen Receptor and Estrogen\/Progesterone Receptors with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, autophagy, and cancer models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"25 mg","offer_id":57805241221465,"sku":"S1191-25MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57805241254233,"sku":"S1191-100MG","price":370.0,"currency_code":"EUR","in_stock":true},{"title":"500 mg","offer_id":57805241287001,"sku":"S1191-500MG","price":861.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57805241319769,"sku":"S1191-1G","price":1346.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57805241352537,"sku":"S1191-1ML\/DMSO","price":193.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/Fulvestrant-Faslodex-chemical-structure-S1191.gif?v=1776173071","url":"https:\/\/absource.de\/products\/fulvestrant-ici-182780-s1191","provider":"Absource Diagnostics","version":"1.0","type":"link"}