{"product_id":"gabbr2-antibody-sc-f2491","title":"GABA B Receptor 2\/GABBR2 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eGABA B receptor 2 (GABBR2) is a subunit of the GABA B receptor, a metabotropic G-protein-coupled receptor (GPCR) that responds to the inhibitory neurotransmitter GABA. GABBR2 partners with GABBR1 to form a functional receptor. Structurally, GABBR2 has an extracellular Venus flytrap (VFT) domain, a seven-helix transmembrane (7TM) domain, and a C-terminal coiled-coil (CC) domain. Depending on the literature source, GABBR2 may also be discussed as GABA B Receptor 2\/GABBR2 and GABA(B)R2.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cell membrane, membrane, postsynaptic cell membrane, and synapse, which can matter when signal is compared across treatments or changing cell states. Following GABBR2 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eGABBR2 is commonly interpreted in the context of cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cell membrane, membrane, and postsynaptic cell membrane, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cell membrane, membrane, and postsynaptic cell membrane across matched conditions\u003c\/li\u003e\n\u003cli\u003esignal-dependent shifts after ligand, inhibitor, or growth-factor perturbation\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003cli\u003etime-matched comparisons so changes reflect biology rather than handling or sampling drift\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for GABBR2. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in GABBR2 reflect biology rather than handling. When interpreting GABBR2, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep GABBR2 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577954672985,"sku":"F2491-20UL","price":199.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577954705753,"sku":"F2491-100UL","price":489.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577954738521,"sku":"F2491-2X100UL","price":729.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F2491-wb.gif?v=1773600462","url":"https:\/\/absource.de\/products\/gabbr2-antibody-sc-f2491","provider":"Absource Diagnostics","version":"1.0","type":"link"}