{"product_id":"gant-61-nsc-136476-s8075","title":"GANT 61 (NSC 136476)","description":"\u003cp\u003e\u003cstrong\u003eGANT 61 (NSC 136476)\u003c\/strong\u003e is an inhibitor of Hedgehog used in studies of Wnt Signaling and Hedgehog Signaling and related signaling programs. In practice, this places the compound in experiments that measure beta-catenin-dependent transcription and developmental signaling and morphogen-dependent developmental signaling and transcriptional patterning in apoptosis, autophagy, and cancer models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting Hedgehog, GANT 61 (NSC 136476) can be used to examine beta-catenin-dependent transcription and developmental signaling and morphogen-dependent developmental signaling and transcriptional patterning. The signaling pathway modulator annotation adds relevance to pathway-reporter and mechanistic-phenotyping studies, together with downstream-response mapping in the same experimental setting. In apoptosis, autophagy, and cancer models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving Hedgehog\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to Wnt Signaling and Hedgehog Signaling and related signaling programs\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003ePathway-reporter and mechanistic-phenotyping studies\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, GANT 61 (NSC 136476) is appropriate when a defined chemical perturbant is needed to connect Hedgehog with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, autophagy, and cancer models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"10 mg","offer_id":57809576493401,"sku":"S8075-10MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"50 mg","offer_id":57809576526169,"sku":"S8075-50MG","price":560.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57809576558937,"sku":"S8075-1G","price":2938.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/GANT-61-chemical-structure-s8075.gif?v=1776202290","url":"https:\/\/absource.de\/products\/gant-61-nsc-136476-s8075","provider":"Absource Diagnostics","version":"1.0","type":"link"}