{"product_id":"gant58-nsc75503-s1182","title":"GANT58 (NSC75503)","description":"\u003cp\u003e\u003cstrong\u003eGANT58 (NSC75503)\u003c\/strong\u003e is an antagonist of Hedgehog used in studies of Hedgehog Signaling and GPCR Signaling. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to morphogen-dependent developmental signaling and transcriptional patterning and receptor-driven second-messenger signaling and desensitization dynamics in cancer and developmental biology models.\u003c\/p\u003e\n\n\u003cp\u003eBy blocking Hedgehog, GANT58 (NSC75503) can be used to examine morphogen-dependent developmental signaling and transcriptional patterning and receptor-driven second-messenger signaling and desensitization dynamics. The signaling pathway modulator annotation adds relevance to pathway-reporter and mechanistic-phenotyping studies, together with downstream-response mapping in the same experimental setting. In cancer and developmental biology models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving Hedgehog\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to Hedgehog Signaling and GPCR Signaling\u003c\/li\u003e\n\u003cli\u003eReceptor-blockade and ligand-competition studies\u003c\/li\u003e\n\u003cli\u003ePathway-reporter and mechanistic-phenotyping studies\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, GANT58 (NSC75503) is appropriate when a defined chemical perturbant is needed to connect Hedgehog with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer and developmental biology models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57805239124313,"sku":"S1182-5MG","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/S1182-GANT58-NSC75503-chemical-structure.png?v=1776173054","url":"https:\/\/absource.de\/products\/gant58-nsc75503-s1182","provider":"Absource Diagnostics","version":"1.0","type":"link"}