{"product_id":"glo1-antibody-sc-f3116","title":"GLO1 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eGlyoxalase 1 (Glo1) is a zinc-dependent metalloenzyme that plays a critical role in cellular detoxification by metabolizing methylglyoxal (MGO), a reactive dicarbonyl compound produced as a byproduct of glycolysis. It is a homodimeric protein that uses glutathione (GSH) as a cofactor to catalyze the isomerization of the hemithioacetal formed spontaneously between MGO and GSH into S-D-lactoylglutathione.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cell membrane, cytoplasm, nucleus, and secreted, which can matter when signal is compared across treatments or changing cell states. Following GLO1 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eGLO1 is commonly interpreted in the context of cancer and metabolism research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cell membrane, cytoplasm, and nucleus, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cell membrane, cytoplasm, and nucleus across matched conditions\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003eresponses linked to nutrient status, mitochondrial state, or metabolic rewiring\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for GLO1. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in GLO1 reflect biology rather than handling. When interpreting GLO1, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep GLO1 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57578002841945,"sku":"F3116-20UL","price":199.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57578002874713,"sku":"F3116-100UL","price":489.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57578002907481,"sku":"F3116-2X100UL","price":729.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F3116-wb.gif?v=1773600938","url":"https:\/\/absource.de\/products\/glo1-antibody-sc-f3116","provider":"Absource Diagnostics","version":"1.0","type":"link"}