{"product_id":"glpg1837-s8698","title":"GLPG1837","description":"\u003cp\u003e\u003cstrong\u003eGLPG1837\u003c\/strong\u003e is an activator of CFTR used in studies of ion-channel pharmacology. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to ion conductance, membrane potential, and electrophysiological responses in cell signaling models. Dose-response comparison, orthogonal validation, and secondary assay follow-up can further sharpen mechanistic interpretation.\u003c\/p\u003e\n\n\u003cp\u003eBy activating CFTR, GLPG1837 can be used to examine ion conductance, membrane potential, and electrophysiological responses. This target class is commonly examined through electrophysiology, ion-flux, and membrane-potential studies, together with downstream-response mapping. In cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving CFTR\u003c\/li\u003e\n\u003cli\u003eGain-of-function pathway-activation studies\u003c\/li\u003e\n\u003cli\u003eElectrophysiology, ion-flux, and membrane-potential studies\u003c\/li\u003e\n\u003cli\u003ePhenotypic profiling in cell signaling models\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, GLPG1837 is appropriate when a defined chemical perturbant is needed to connect CFTR with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"2 mg","offer_id":57809638097241,"sku":"S8698-2MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"5 mg","offer_id":57809638130009,"sku":"S8698-5MG","price":213.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57809638162777,"sku":"S8698-25MG","price":658.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/glpg1837-chemical-structure-s8698.gif?v=1776204654","url":"https:\/\/absource.de\/products\/glpg1837-s8698","provider":"Absource Diagnostics","version":"1.0","type":"link"}