{"product_id":"gne-987-e1664","title":"GNE-987","description":"\u003cp\u003e\u003cstrong\u003eGNE-987\u003c\/strong\u003e is a modulator of BET used in studies of Apoptosis and Protein Degradation \/ Proteasome and related signaling programs. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to caspase-associated cell-death signaling and survival decisions and ubiquitin-dependent turnover, proteostasis, and targeted protein degradation in apoptosis, cancer, and epigenetics models.\u003c\/p\u003e\n\n\u003cp\u003eBy modulating BET, GNE-987 can be used to examine caspase-associated cell-death signaling and survival decisions and ubiquitin-dependent turnover, proteostasis, and targeted protein degradation. The epigenetic regulator annotation adds relevance to chromatin, epigenetic, and gene-expression profiling, together with downstream-response mapping in the same experimental setting. In apoptosis, cancer, and epigenetics models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving BET\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to Apoptosis and Protein Degradation \/ Proteasome and related signaling programs\u003c\/li\u003e\n\u003cli\u003eContext-dependent response profiling and mechanism comparison\u003c\/li\u003e\n\u003cli\u003eChromatin, epigenetic, and gene-expression profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, GNE-987 is appropriate when a defined chemical perturbant is needed to connect BET with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, cancer, and epigenetics models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"1 mg","offer_id":57804430115161,"sku":"E1664-1MG","price":193.0,"currency_code":"EUR","in_stock":true},{"title":"5 mg","offer_id":57804430147929,"sku":"E1664-5MG","price":341.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57804430180697,"sku":"E1664-25MG","price":763.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57804430213465,"sku":"E1664-100MG","price":1739.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/E1664-GNE-987-chemical-structure.png?v=1776167136","url":"https:\/\/absource.de\/products\/gne-987-e1664","provider":"Absource Diagnostics","version":"1.0","type":"link"}