{"product_id":"gria2-antibody-sc-f1223","title":"AMPA Receptor 2 (GluA2) Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eGRIA2 is a target of interest in many antibody-based workflows. AMPA subtype glutamate receptors (AMPARs) are key mediators of fast excitatory synaptic transmission and are crucial for long-term synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD), which are models for learning and memory. In hippocampal CA1 pyramidal neurons, most AMPARs are heteromeric complexes of GluA1 and GluA2 subunits. Depending on the literature source, GRIA2 may also be discussed as AMPA Receptor 2 (GluA2).\u003c\/p\u003e\u003cp\u003eReported cellular context includes cell membrane, membrane, postsynaptic cell membrane, and synapse, which can matter when signal is compared across treatments or changing cell states. Following GRIA2 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eGRIA2 is commonly interpreted in the context of neuroscience and developmental biology research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cell membrane, membrane, and postsynaptic cell membrane, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cell membrane, membrane, and postsynaptic cell membrane across matched conditions\u003c\/li\u003e\n\u003cli\u003ecompartment-specific patterns relevant to neuronal polarity, transport, or synaptic context\u003c\/li\u003e\n\u003cli\u003estage-dependent patterns during differentiation, morphogenesis, or lineage commitment\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for GRIA2. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in GRIA2 reflect biology rather than handling. When interpreting GRIA2, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep GRIA2 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577664020825,"sku":"F1223-20UL","price":149.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577664053593,"sku":"F1223-100UL","price":329.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577664086361,"sku":"F1223-2X100UL","price":489.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F1223-wb.gif?v=1773599465","url":"https:\/\/absource.de\/products\/gria2-antibody-sc-f1223","provider":"Absource Diagnostics","version":"1.0","type":"link"}