{"product_id":"gsk2643943a-s6878","title":"GSK2643943A","description":"\u003cp\u003e\u003cstrong\u003eGSK2643943A\u003c\/strong\u003e is an inhibitor of DUB and Rho GTPases used in studies of Protein Degradation \/ Proteasome. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to ubiquitin-dependent turnover, proteostasis, and targeted protein degradation in cancer, cell signaling, and protein homeostasis models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting DUB and Rho GTPases, GSK2643943A can be used to examine ubiquitin-dependent turnover, proteostasis, and targeted protein degradation. The enzyme annotation adds relevance to enzyme-activity assays, substrate-conversion studies, and mechanism profiling, together with downstream-response mapping in the same experimental setting. In cancer, cell signaling, and protein homeostasis models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving DUB and Rho GTPases\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to Protein Degradation \/ Proteasome\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eEnzyme-activity assays, substrate-conversion studies, and mechanism profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, GSK2643943A is appropriate when a defined chemical perturbant is needed to connect DUB and Rho GTPases with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell signaling, and protein homeostasis models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57809433624921,"sku":"S6878-5MG","price":213.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57809433657689,"sku":"S6878-25MG","price":658.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/s6878-gsk2643943a-chemical-structure.gif?v=1776200623","url":"https:\/\/absource.de\/products\/gsk2643943a-s6878","provider":"Absource Diagnostics","version":"1.0","type":"link"}