{"product_id":"gsk269962a-s7512","title":"GSK269962A","description":"\u003cp\u003e\u003cstrong\u003eGSK269962A\u003c\/strong\u003e is an inhibitor of ROCK and ROCK1 and related targets used in studies of kinase signaling. In practice, this places the compound in experiments that measure phosphorylation signaling, target engagement, and selectivity relationships in cancer, cardiovascular, and cell cycle models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting ROCK and ROCK1 and related targets, GSK269962A can be used to examine phosphorylation signaling, target engagement, and selectivity relationships. This target class is commonly examined through biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping. In cancer, cardiovascular, and cell cycle models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving ROCK and ROCK1 and related targets\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eBiochemical kinase assays, phospho-signaling studies, and selectivity profiling\u003c\/li\u003e\n\u003cli\u003ePhenotypic profiling in cancer, cardiovascular, and cell cycle models\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, GSK269962A is appropriate when a defined chemical perturbant is needed to connect ROCK and ROCK1 and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cardiovascular, and cell cycle models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57809491394905,"sku":"S7512-5MG","price":193.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57809491427673,"sku":"S7512-25MG","price":488.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57809491460441,"sku":"S7512-100MG","price":953.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57809491493209,"sku":"S7512-1G","price":2918.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/S7512-GSK269962A-chemical-structure.png?v=1776201497","url":"https:\/\/absource.de\/products\/gsk269962a-s7512","provider":"Absource Diagnostics","version":"1.0","type":"link"}