{"product_id":"hi-topk-032-s6882","title":"HI-TOPK-032","description":"\u003cp\u003e\u003cstrong\u003eHI-TOPK-032\u003c\/strong\u003e is an inhibitor of p53 and ERK and related targets used in studies of MAPK \/ ERK Signaling and DNA Damage Response and related signaling programs. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and checkpoint activation, DNA repair, and genome-stability control in apoptosis, cancer, and cell cycle models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting p53 and ERK and related targets, HI-TOPK-032 can be used to examine mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and checkpoint activation, DNA repair, and genome-stability control. This context is compatible with phosphorylation mapping, pathway-response, and growth assays and DNA-repair, checkpoint, and genotoxic-stress assays, as well as transcriptional, biochemical, or phenotypic comparisons linked to the annotated pathway state. In apoptosis, cancer, and cell cycle models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving p53 and ERK and related targets\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to MAPK \/ ERK Signaling and DNA Damage Response and related signaling programs\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003ePhenotypic profiling in apoptosis, cancer, and cell cycle models\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, HI-TOPK-032 is appropriate when a defined chemical perturbant is needed to connect p53 and ERK and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, cancer, and cell cycle models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57809433887065,"sku":"S6882-5MG","price":124.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57809433919833,"sku":"S6882-25MG","price":383.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/s6882-hi-topk-032-chemical-structure.gif?v=1776200629","url":"https:\/\/absource.de\/products\/hi-topk-032-s6882","provider":"Absource Diagnostics","version":"1.0","type":"link"}