{"product_id":"histone-h4-antibody-sc-f0826","title":"Acetyl-Histone H4 (Lys12) Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eHistone H4 is a target of interest in many antibody-based workflows. Initially perceived as a static framework for DNA organization, the nucleosome, composed of four core histone proteins (H2A, H2B, H3, and H4), has been recognized as a dynamic entity undergoing various post-translational modifications. These modifications include acetylation, phosphorylation, methylation, and ubiquitination. Histone acetylation predominantly targets the amino-terminal tail regions of histones H2A (Lys5), H2B (Lys5, 12, 15, and 20), H3 (Lys9, 14, 18, 23, 27, 36, and 56), and H4 (Lys5, 8, 12, and 16), exerting regulatory effects on histone deposition, transcriptional activation, DNA replication, recombination, and DNA repair. Depending on the literature source, Histone H4 may also be discussed as Acetyl-Histone H4 (Lys12) and Histone H4 (acetyl K12).\u003c\/p\u003e\u003cp\u003eReported cellular context includes chromosome, nucleosome core, and nucleus, which can matter when signal is compared across treatments or changing cell states. Following Histone H4 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eHistone H4 is commonly interpreted in the context of epigenetics research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans chromosome, nucleosome core, and nucleus, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between chromosome, nucleosome core, and nucleus across matched conditions\u003c\/li\u003e\n\u003cli\u003elinks between target behavior and transcriptional or chromatin-state changes\u003c\/li\u003e\n\u003cli\u003edifferences between total target abundance and site-specific regulation when modified forms are compared\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for Histone H4. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in Histone H4 reflect biology rather than handling. When interpreting Histone H4, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep Histone H4 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"Selleck \/ 20 µl","offer_id":57577531179353,"sku":"F0826-20UL","price":169.0,"currency_code":"EUR","in_stock":true},{"title":"Selleck \/ 100 µl","offer_id":57577531212121,"sku":"F0826-100UL","price":389.0,"currency_code":"EUR","in_stock":true},{"title":"Selleck \/ 2 × 100 µl","offer_id":57577531244889,"sku":"F0826-2X100UL","price":579.0,"currency_code":"EUR","in_stock":true},{"title":"Capsid \/ 20 µl","offer_id":58449916297561,"sku":"C05451-20UL","price":136.0,"currency_code":"EUR","in_stock":true},{"title":"Capsid \/ 100 µl","offer_id":58449916330329,"sku":"C05451-100UL","price":313.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F0826-IF.png?v=1773598992","url":"https:\/\/absource.de\/products\/histone-h4-antibody-sc-f0826","provider":"Absource Diagnostics","version":"1.0","type":"link"}