{"product_id":"hsp105-hsp110-antibody-sc-f3718","title":"Hsp105\/HSP110 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eHsp105\/HSP110 is a molecular chaperone belonging to the Hsp70 superfamily, distinguished by its dual function as a nucleotide exchange factor (NEF) for Hsp70 chaperones and as an independent ATP-dependent \"holdase\" chaperone that prevents protein aggregation during cellular stress. It consists of two main domains: an N-terminal nucleotide-binding domain (NBD) responsible for ATP binding and hydrolysis, critical for energy transduction, and a C-terminal substrate-binding domain (SBD) that recognizes and stabilizes unfolded or misfolded polypeptides. Depending on the literature source, Hsp105\/HSP110 may also be discussed as Hsp105\/HSP110 and HSP105.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cytoplasm, which can matter when signal is compared across treatments or changing cell states. Following Hsp105\/HSP110 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eHsp105\/HSP110 is commonly interpreted in the context of immunology research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cytoplasm, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003esignal enrichment within cytoplasm relative to the broader cellular background\u003c\/li\u003e\n\u003cli\u003econtext differences tied to immune-cell state, activation, or lineage composition\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003cli\u003etime-matched comparisons so changes reflect biology rather than handling or sampling drift\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for Hsp105\/HSP110. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in Hsp105\/HSP110 reflect biology rather than handling. When interpreting Hsp105\/HSP110, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep Hsp105\/HSP110 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57578041213273,"sku":"F3718-20UL","price":199.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57578041246041,"sku":"F3718-100UL","price":489.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57578041278809,"sku":"F3718-2X100UL","price":729.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F3718-IF.png?v=1773601412","url":"https:\/\/absource.de\/products\/hsp105-hsp110-antibody-sc-f3718","provider":"Absource Diagnostics","version":"1.0","type":"link"}