{"product_id":"igf-1r-antibody-sc-f0398","title":"Phospho-IGF-1R β (Tyr1135) Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eIGF-1R is a target of interest in many antibody-based workflows. Phospho-IGF-I Receptor β (Tyr1135) refers to the phosphorylated form of tyrosine residue 1135 on the β-subunit of the insulin-like growth factor I receptor (IGF-IR), a transmembrane heterotetrameric tyrosine kinase receptor composed of two extracellular α-subunits and two intracellular β-subunits. Tyr1135 resides within the kinase domain of the β-subunit and plays a critical role in the receptor’s activation upon IGF-I binding. Depending on the literature source, IGF-1R may also be discussed as Phospho-IGF-1R beta (Tyr1135).\u003c\/p\u003e\u003cp\u003eReported cellular context includes cell membrane and membrane, which can matter when signal is compared across treatments or changing cell states. Following IGF-1R across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eIGF-1R is commonly interpreted in the context of cancer, developmental biology, and endocrinology research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cell membrane and membrane, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cell membrane and membrane across matched conditions\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003estage-dependent patterns during differentiation, morphogenesis, or lineage commitment\u003c\/li\u003e\n\u003cli\u003eresponses to hormone-dependent signaling or endocrine feedback context\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for IGF-1R. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in IGF-1R reflect biology rather than handling. When interpreting IGF-1R, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep IGF-1R trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577449292121,"sku":"F0398-20UL","price":139.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577449324889,"sku":"F0398-100UL","price":329.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577449357657,"sku":"F0398-2X100UL","price":489.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F0398-wb.gif?v=1773598412","url":"https:\/\/absource.de\/products\/igf-1r-antibody-sc-f0398","provider":"Absource Diagnostics","version":"1.0","type":"link"}