{"product_id":"igf2r-antibody-sc-f1040","title":"M6PR (cation independent) Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eIGF2R is a target of interest in many antibody-based workflows. The cation-independent mannose 6-phosphate receptor (CI-MPR) is a crucial player in cellular degradation and lysosomal enzyme transport, featuring a 300-kDa size and a complex structure with 15 mannose 6-phosphate receptor homology (MRH) domains. This large extracellular receptor binds approximately 60 different mannose 6-phosphate (Man-6-P)-tagged lysosomal enzymes, directing them from the Golgi to the endosomal\/lysosomal system. Depending on the literature source, IGF2R may also be discussed as M6PR (cation independent) and IGF-II R.\u003c\/p\u003e\u003cp\u003eReported cellular context includes endosome, golgi apparatus, and membrane, which can matter when signal is compared across treatments or changing cell states. Following IGF2R across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eIGF2R is commonly interpreted in the context of cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans endosome, golgi apparatus, and membrane, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between endosome, golgi apparatus, and membrane across matched conditions\u003c\/li\u003e\n\u003cli\u003esignal-dependent shifts after ligand, inhibitor, or growth-factor perturbation\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003cli\u003etime-matched comparisons so changes reflect biology rather than handling or sampling drift\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for IGF2R. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in IGF2R reflect biology rather than handling. When interpreting IGF2R, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep IGF2R trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577594847577,"sku":"F1040-20UL","price":149.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577594880345,"sku":"F1040-100UL","price":329.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577594913113,"sku":"F1040-2X100UL","price":489.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F1040-IHC1.jpg?v=1773599213","url":"https:\/\/absource.de\/products\/igf2r-antibody-sc-f1040","provider":"Absource Diagnostics","version":"1.0","type":"link"}