{"product_id":"irinotecan-hydrochloride-trihydrate-s2217","title":"Irinotecan Hydrochloride Trihydrate","description":"\u003cp\u003e\u003cstrong\u003eIrinotecan Hydrochloride Trihydrate\u003c\/strong\u003e is an inhibitor of Topoisomerase used in studies of DNA Damage Response. It is especially relevant in cancer and dna damage \/ repair models, where defined compound exposure can be linked to checkpoint activation, DNA repair, and genome-stability control.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting Topoisomerase, Irinotecan Hydrochloride Trihydrate can be used to examine checkpoint activation, DNA repair, and genome-stability control. The enzyme annotation adds relevance to enzyme-activity assays, substrate-conversion studies, and mechanism profiling, together with downstream-response mapping in the same experimental setting. In cancer and dna damage \/ repair models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving Topoisomerase\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to DNA Damage Response\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eEnzyme-activity assays, substrate-conversion studies, and mechanism profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Irinotecan Hydrochloride Trihydrate is appropriate when a defined chemical perturbant is needed to connect Topoisomerase with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer and dna damage \/ repair models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57805468139865,"sku":"S2217-5MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57805468172633,"sku":"S2217-25MG","price":291.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57805468205401,"sku":"S2217-100MG","price":519.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57805468238169,"sku":"S2217-1G","price":953.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57805468270937,"sku":"S2217-1ML\/DMSO","price":186.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/Irinotecan-HCl-Trihydrate-Campto-chemical-structure-S2217.gif?v=1776174652","url":"https:\/\/absource.de\/products\/irinotecan-hydrochloride-trihydrate-s2217","provider":"Absource Diagnostics","version":"1.0","type":"link"}