{"product_id":"irs-1-antibody-sc-f0386","title":"IRS-1 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eThe Insulin Receptor Substrate (IRS) proteins constitute a family of cytoplasmic adaptor proteins crucial for insulin signaling. IRS-1, the first identified family member, was initially noted as a 185 kD phosphoprotein. Both IRS-1 and IRS-2 are widely expressed and serve as principal mediators of insulin-dependent mitogenesis and the regulation of glucose metabolism across various cell types. Depending on the literature source, IRS-1 may also be discussed as IRS1+IRS2.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cytoplasm, nucleoplasm, nucleus, and plasma membrane, which can matter when signal is compared across treatments or changing cell states. Following IRS-1 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eIRS-1 is commonly interpreted in the context of cancer, metabolism, and endocrinology research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cytoplasm, nucleoplasm, and nucleus, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cytoplasm, nucleoplasm, and nucleus across matched conditions\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003eresponses linked to nutrient status, mitochondrial state, or metabolic rewiring\u003c\/li\u003e\n\u003cli\u003eresponses to hormone-dependent signaling or endocrine feedback context\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for IRS-1. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in IRS-1 reflect biology rather than handling. When interpreting IRS-1, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep IRS-1 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577448702297,"sku":"F0386-20UL","price":139.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577448735065,"sku":"F0386-100UL","price":329.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577448767833,"sku":"F0386-2X100UL","price":489.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F0386-wb.gif?v=1773598402","url":"https:\/\/absource.de\/products\/irs-1-antibody-sc-f0386","provider":"Absource Diagnostics","version":"1.0","type":"link"}