{"product_id":"itpr1-antibody-sc-f0840","title":"IP3 Receptor 1 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eITPR1 is a target of interest in many antibody-based workflows. Inositol-1,4,5-trisphosphate receptors (InsP3Rs) are large, ubiquitous ion channels that mediate Ca²⁺ release from intracellular stores like the endoplasmic reticulum (ER) and Golgi apparatus. Vertebrates have three closely related InsP3R subtypes (IP3R1-3) that form homo- and heterotetrameric channels. Each InsP3R subunit is composed of approximately 2700 amino acids and contains ten domains responsible for channel stability, ion transport, ligand binding, and regulation. Depending on the literature source, ITPR1 may also be discussed as IP3 Receptor 1 and IP3 receptor.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cytoplasm, cytoplasmic vesicle, endoplasmic reticulum, and membrane, which can matter when signal is compared across treatments or changing cell states. Following ITPR1 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eITPR1 is commonly interpreted in the context of cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cytoplasm, cytoplasmic vesicle, and endoplasmic reticulum, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cytoplasm, cytoplasmic vesicle, and endoplasmic reticulum across matched conditions\u003c\/li\u003e\n\u003cli\u003esignal-dependent shifts after ligand, inhibitor, or growth-factor perturbation\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003cli\u003etime-matched comparisons so changes reflect biology rather than handling or sampling drift\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for ITPR1. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in ITPR1 reflect biology rather than handling. When interpreting ITPR1, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep ITPR1 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577531965785,"sku":"F0840-20UL","price":149.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577531998553,"sku":"F0840-100UL","price":329.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577532031321,"sku":"F0840-2X100UL","price":489.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F0840-wb.gif?v=1773599000","url":"https:\/\/absource.de\/products\/itpr1-antibody-sc-f0840","provider":"Absource Diagnostics","version":"1.0","type":"link"}