{"product_id":"jarid1a-antibody-sc-f2640","title":"JARID1A Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eJARID1A (KDM5A\/RBP2) is a nuclear histone demethylase of the KDM5 family that removes tri- and dimethyl groups from H3K4, generally repressing transcription. Structurally, it contains catalytic JmjN and JmjC domains, an ARID DNA-binding domain, and three PHD fingers (PHD1-PHD3) that mediate histone recognition and protein-protein interactions, including direct binding of its PHD2 domain to the hematopoietic transcription factor GATA1. Depending on the literature source, JARID1A may also be discussed as ARID; demethylase; Jmjc; Jumonji; Jumonji\/ARID domain-containing protein 1A; RBBP-2.\u003c\/p\u003e\u003cp\u003eReported cellular context includes nucleus, which can matter when signal is compared across treatments or changing cell states. Following JARID1A across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eJARID1A is commonly interpreted in the context of cancer, developmental biology, and epigenetics research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans nucleus, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003esignal enrichment within nucleus relative to the broader cellular background\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003estage-dependent patterns during differentiation, morphogenesis, or lineage commitment\u003c\/li\u003e\n\u003cli\u003elinks between target behavior and transcriptional or chromatin-state changes\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for JARID1A. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in JARID1A reflect biology rather than handling. When interpreting JARID1A, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep JARID1A trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577965420889,"sku":"F2640-20UL","price":139.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577965453657,"sku":"F2640-100UL","price":319.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577965486425,"sku":"F2640-2X100UL","price":479.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F2640-wb.gif?v=1773600602","url":"https:\/\/absource.de\/products\/jarid1a-antibody-sc-f2640","provider":"Absource Diagnostics","version":"1.0","type":"link"}