{"product_id":"jnj-63576253-trc-253-s9900","title":"JNJ-63576253 (TRC-253)","description":"\u003cp\u003e\u003cstrong\u003eJNJ-63576253 (TRC-253)\u003c\/strong\u003e is an antagonist of Androgen Receptor used in studies of Hormone Signaling. In practice, this places the compound in experiments that measure ligand-dependent transcriptional programs and endocrine regulation in cancer and endocrinology models.\u003c\/p\u003e\n\n\u003cp\u003eBy blocking Androgen Receptor, JNJ-63576253 (TRC-253) can be used to examine ligand-dependent transcriptional programs and endocrine regulation. The nuclear receptor annotation adds relevance to reporter-gene, receptor-binding, and transcriptional assays, together with downstream-response mapping in the same experimental setting. In cancer and endocrinology models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving Androgen Receptor\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to Hormone Signaling\u003c\/li\u003e\n\u003cli\u003eReceptor-blockade and ligand-competition studies\u003c\/li\u003e\n\u003cli\u003eReporter-gene, receptor-binding, and transcriptional assays\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, JNJ-63576253 (TRC-253) is appropriate when a defined chemical perturbant is needed to connect Androgen Receptor with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer and endocrinology models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57809756946777,"sku":"S9900-5MG","price":124.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57809756979545,"sku":"S9900-25MG","price":380.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/s9900-jnj-63576253-trc-253--chemical-structure.gif?v=1776205274","url":"https:\/\/absource.de\/products\/jnj-63576253-trc-253-s9900","provider":"Absource Diagnostics","version":"1.0","type":"link"}