{"product_id":"ku-60019-s1570","title":"KU-60019","description":"\u003cp\u003e\u003cstrong\u003eKU-60019\u003c\/strong\u003e is an inhibitor of ATM and ATR used in studies of DNA Damage Response. It is especially relevant in cancer, cell signaling, and dna damage \/ repair models, where defined compound exposure can be linked to checkpoint activation, DNA repair, and genome-stability control.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting ATM and ATR, KU-60019 can be used to examine checkpoint activation, DNA repair, and genome-stability control. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In cancer, cell signaling, and dna damage \/ repair models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving ATM and ATR\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to DNA Damage Response\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eBiochemical kinase assays, phospho-signaling studies, and selectivity profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, KU-60019 is appropriate when a defined chemical perturbant is needed to connect ATM and ATR with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell signaling, and dna damage \/ repair models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"10 mg","offer_id":57805314097497,"sku":"S1570-10MG","price":193.0,"currency_code":"EUR","in_stock":true},{"title":"50 mg","offer_id":57805314130265,"sku":"S1570-50MG","price":560.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57805314163033,"sku":"S1570-1ML\/DMSO","price":265.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/KU-60019-chemical-structure-S1570.gif?v=1776173746","url":"https:\/\/absource.de\/products\/ku-60019-s1570","provider":"Absource Diagnostics","version":"1.0","type":"link"}