{"product_id":"ku70-antibody-sc-f4068","title":"Ku70 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eHuman Ku70 is a key nuclear protein that plays a central role in the non-homologous end joining (NHEJ) pathway for repairing DNA double-strand breaks. It is encoded by the XRCC6 gene on chromosome 22, while its partner protein Ku80 is encoded by XRCC5 on chromosome 2. Depending on the literature source, KU70 may also be discussed as G22P1 and XRCC6.\u003c\/p\u003e\u003cp\u003eReported cellular context includes chromosome, cytoplasm, and nucleus, which can matter when signal is compared across treatments or changing cell states. Following KU70 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eKU70 is commonly interpreted in the context of immunology, dna damage \/ repair, and cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans chromosome, cytoplasm, and nucleus, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between chromosome, cytoplasm, and nucleus across matched conditions\u003c\/li\u003e\n\u003cli\u003econtext differences tied to immune-cell state, activation, or lineage composition\u003c\/li\u003e\n\u003cli\u003estress-induced changes after checkpoint activation or genotoxic challenge\u003c\/li\u003e\n\u003cli\u003esignal-dependent shifts after ligand, inhibitor, or growth-factor perturbation\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for KU70. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in KU70 reflect biology rather than handling. When interpreting KU70, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep KU70 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57578057007449,"sku":"F4068-20UL","price":149.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57578057040217,"sku":"F4068-100UL","price":329.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57578057072985,"sku":"F4068-2X100UL","price":489.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F4068-IF.png?v=1773601639","url":"https:\/\/absource.de\/products\/ku70-antibody-sc-f4068","provider":"Absource Diagnostics","version":"1.0","type":"link"}