{"product_id":"lasp1-antibody-sc-f3622","title":"LASP1 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eLASP1 (LIM and SH3 Protein 1) is a multifunctional scaffolding protein that integrates cytoskeletal dynamics, intracellular signaling, and nuclear functions, playing key roles in cancer progression and tissue remodelling. Structurally, it contains an N-terminal LIM domain with zinc-finger motifs, central nebulin-like repeats for F-actin binding, and a C-terminal SH3 domain that interacts with proline-rich sequences of partner proteins, enabling its localization to focal adhesions, lamellipodia, and invadopodia. Depending on the literature source, LASP1 may also be discussed as MLN50 and LIM and SH3 domain protein 1.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cytoplasm and cytoskeleton, which can matter when signal is compared across treatments or changing cell states. Following LASP1 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eLASP1 is commonly interpreted in the context of cancer, epigenetics, and cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cytoplasm and cytoskeleton, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cytoplasm and cytoskeleton across matched conditions\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003elinks between target behavior and transcriptional or chromatin-state changes\u003c\/li\u003e\n\u003cli\u003esignal-dependent shifts after ligand, inhibitor, or growth-factor perturbation\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for LASP1. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in LASP1 reflect biology rather than handling. When interpreting LASP1, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep LASP1 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"Selleck \/ 20 µl","offer_id":57578036396377,"sku":"F3622-20UL","price":95.0,"currency_code":"EUR","in_stock":true},{"title":"Selleck \/ 100 µl","offer_id":57578036429145,"sku":"F3622-100UL","price":299.0,"currency_code":"EUR","in_stock":true},{"title":"Selleck \/ 2 × 100 µl","offer_id":57578036461913,"sku":"F3622-2X100UL","price":479.0,"currency_code":"EUR","in_stock":true},{"title":"Capsid \/ 20 µl","offer_id":58477559152985,"sku":"C06709-20UL","price":95.0,"currency_code":"EUR","in_stock":true},{"title":"Capsid \/ 100 µl","offer_id":58477559185753,"sku":"C06709-100UL","price":234.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F3622-IF.png?v=1773601342","url":"https:\/\/absource.de\/products\/lasp1-antibody-sc-f3622","provider":"Absource Diagnostics","version":"1.0","type":"link"}