{"product_id":"leniolisib-cdz-173-s8752","title":"leniolisib (CDZ 173)","description":"\u003cp\u003e\u003cstrong\u003eleniolisib (CDZ 173)\u003c\/strong\u003e is an inhibitor of PI3K and DNA-PK and related targets used in studies of PI3K-Akt-mTOR Signaling and DNA Damage Response. In practice, this places the compound in experiments that measure growth-factor signaling, survival control, and nutrient-sensing outputs and checkpoint activation, DNA repair, and genome-stability control in cancer, cell signaling, and dna damage \/ repair models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting PI3K and DNA-PK and related targets, leniolisib (CDZ 173) can be used to examine growth-factor signaling, survival control, and nutrient-sensing outputs and checkpoint activation, DNA repair, and genome-stability control. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In cancer, cell signaling, and dna damage \/ repair models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving PI3K and DNA-PK and related targets\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to PI3K-Akt-mTOR Signaling and DNA Damage Response\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eBiochemical kinase assays, phospho-signaling studies, and selectivity profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, leniolisib (CDZ 173) is appropriate when a defined chemical perturbant is needed to connect PI3K and DNA-PK and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell signaling, and dna damage \/ repair models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"Selleck \/ 5 mg","offer_id":57809644880217,"sku":"S8752-5MG","price":223.0,"currency_code":"EUR","in_stock":true},{"title":"Selleck \/ 25 mg","offer_id":57809644912985,"sku":"S8752-25MG","price":658.0,"currency_code":"EUR","in_stock":true},{"title":"Capsid \/ 5 mg","offer_id":58479026438489,"sku":"C13640-5MG","price":167.0,"currency_code":"EUR","in_stock":true},{"title":"Capsid \/ 25 mg","offer_id":58479026471257,"sku":"C13640-25MG","price":492.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/leniolisib-cdz-173-chemical-structure-s8752.gif?v=1776204706","url":"https:\/\/absource.de\/products\/leniolisib-cdz-173-s8752","provider":"Absource Diagnostics","version":"1.0","type":"link"}