{"product_id":"lfp40-antibody-sc-f3891","title":"GEF H1 C-terminal Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eLFP40 is a target of interest in many antibody-based workflows. The Rho family of small GTPases plays a central role in regulating key cellular functions such as migration, adhesion, proliferation, and differentiation. Their activation is mediated by guanine nucleotide exchange factors (GEFs), which facilitate the exchange of GDP for GTP. GEF-H1 (also known as ARHGEF2) is a Rho-specific GEF that associates with microtubules and modulates Rho activity, particularly in response to microtubule destabilization. Depending on the literature source, LFP40 may also be discussed as GEF H1 C-terminal and KIAA0651.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cell junction, cell membrane, cell projection, and cytoplasm, which can matter when signal is compared across treatments or changing cell states. Following LFP40 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eLFP40 is commonly interpreted in the context of cancer and cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cell junction, cell membrane, and cell projection, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cell junction, cell membrane, and cell projection across matched conditions\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003esignal-dependent shifts after ligand, inhibitor, or growth-factor perturbation\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for LFP40. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in LFP40 reflect biology rather than handling. When interpreting LFP40, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep LFP40 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57578051699033,"sku":"F3891-20UL","price":149.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57578051731801,"sku":"F3891-100UL","price":319.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57578051764569,"sku":"F3891-2X100UL","price":479.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F3891-IF.png?v=1773601553","url":"https:\/\/absource.de\/products\/lfp40-antibody-sc-f3891","provider":"Absource Diagnostics","version":"1.0","type":"link"}