{"product_id":"lgr5-antibody-sc-f2247","title":"LGR5 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eLeucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5), also known as GPR49, is a seven-transmembrane protein belonging to the class A Rhodopsin-like family of GPCRs. It is characterized by a large extracellular domain with 17 leucine-rich repeat (LRR) sequences, a linker region, and a seven-transmembrane helical domain.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cell membrane, golgi apparatus, and membrane, which can matter when signal is compared across treatments or changing cell states. Following LGR5 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eLGR5 is commonly interpreted in the context of developmental biology, stem cell biology, and cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cell membrane, golgi apparatus, and membrane, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cell membrane, golgi apparatus, and membrane across matched conditions\u003c\/li\u003e\n\u003cli\u003estage-dependent patterns during differentiation, morphogenesis, or lineage commitment\u003c\/li\u003e\n\u003cli\u003estate transitions between self-renewal, priming, and differentiation\u003c\/li\u003e\n\u003cli\u003esignal-dependent shifts after ligand, inhibitor, or growth-factor perturbation\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for LGR5. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in LGR5 reflect biology rather than handling. When interpreting LGR5, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep LGR5 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577904996697,"sku":"F2247-20UL","price":199.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577905029465,"sku":"F2247-100UL","price":489.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577905062233,"sku":"F2247-2X100UL","price":729.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F2247-wb.gif?v=1773600300","url":"https:\/\/absource.de\/products\/lgr5-antibody-sc-f2247","provider":"Absource Diagnostics","version":"1.0","type":"link"}