{"product_id":"lgr6-antibody-sc-f3304","title":"GPCR LGR6 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eGPCR LGR6 (Leucine-rich repeat-containing G protein-coupled receptor 6) is a member of the glycoprotein hormone receptor subfamily within the rhodopsin-like class of seven-transmembrane domain (7TM) G protein-coupled receptors (GPCRs). Structurally, LGR6 is characterized by a large extracellular domain (ECD) containing 17 leucine-rich repeats flanked by cysteine-rich regions at both the N- and C-termini, which facilitate ligand binding and receptor activation. Depending on the literature source, LGR6 may also be discussed as GPCR LGR6 and UNQ6427\/PRO21331.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cellmembrane and membrane, which can matter when signal is compared across treatments or changing cell states. Following LGR6 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eLGR6 is commonly interpreted in the context of cancer and cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cellmembrane and membrane, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cellmembrane and membrane across matched conditions\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003esignal-dependent shifts after ligand, inhibitor, or growth-factor perturbation\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for LGR6. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in LGR6 reflect biology rather than handling. When interpreting LGR6, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep LGR6 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57578013983065,"sku":"F3304-20UL","price":199.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57578014015833,"sku":"F3304-100UL","price":489.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57578014048601,"sku":"F3304-2X100UL","price":729.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F3304-IF.png?v=1773601097","url":"https:\/\/absource.de\/products\/lgr6-antibody-sc-f3304","provider":"Absource Diagnostics","version":"1.0","type":"link"}