{"product_id":"linsitinib-osi-906-s1091","title":"Linsitinib (OSI-906)","description":"\u003cp\u003e\u003cstrong\u003eLinsitinib (OSI-906)\u003c\/strong\u003e is an inhibitor of IGF-1R and Insulin Receptor used in studies of PI3K-Akt-mTOR Signaling and MAPK \/ ERK Signaling. In practice, this places the compound in experiments that measure growth-factor signaling, survival control, and nutrient-sensing outputs and mitogenic kinase cascades, proliferation control, and differentiation-linked signaling in cancer, cell signaling, and endocrinology models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting IGF-1R and Insulin Receptor, Linsitinib (OSI-906) can be used to examine growth-factor signaling, survival control, and nutrient-sensing outputs and mitogenic kinase cascades, proliferation control, and differentiation-linked signaling. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In cancer, cell signaling, and endocrinology models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving IGF-1R and Insulin Receptor\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to PI3K-Akt-mTOR Signaling and MAPK \/ ERK Signaling\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eBiochemical kinase assays, phospho-signaling studies, and selectivity profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Linsitinib (OSI-906) is appropriate when a defined chemical perturbant is needed to connect IGF-1R and Insulin Receptor with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell signaling, and endocrinology models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57805218480473,"sku":"S1091-5MG","price":167.0,"currency_code":"EUR","in_stock":true},{"title":"50 mg","offer_id":57805218513241,"sku":"S1091-50MG","price":707.0,"currency_code":"EUR","in_stock":true},{"title":"200 mg","offer_id":57805218546009,"sku":"S1091-200MG","price":1641.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57805218578777,"sku":"S1091-1G","price":2938.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57805218611545,"sku":"S1091-1ML\/DMSO","price":265.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/OSI-906-chemical-structure-s1091.gif?v=1776172883","url":"https:\/\/absource.de\/products\/linsitinib-osi-906-s1091","provider":"Absource Diagnostics","version":"1.0","type":"link"}