{"product_id":"lsd1-antibody-sc-f0438","title":"LSD1 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eLysine-specific demethylase 1 (LSD1), also referred to as AOF2 and BHC110, is a nuclear amine oxidase homolog with roles as a histone demethylase and transcriptional cofactor. LSD1 is a key component of the CoREST transcriptional co-repressor complex, alongside CoREST, CtBP, HDAC1, and HDAC2. Within this complex, LSD1 performs demethylation of mono- and di-methyl histone H3 at Lys4 via a FAD-dependent oxidation reaction, thereby facilitating the repression of neuronal-specific genes in non-neuronal cells. Depending on the literature source, LSD1 may also be discussed as KDM1.\u003c\/p\u003e\u003cp\u003eReported cellular context includes chromosome and nucleus, which can matter when signal is compared across treatments or changing cell states. Following LSD1 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eLSD1 is commonly interpreted in the context of neuroscience, epigenetics, and cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans chromosome and nucleus, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between chromosome and nucleus across matched conditions\u003c\/li\u003e\n\u003cli\u003ecompartment-specific patterns relevant to neuronal polarity, transport, or synaptic context\u003c\/li\u003e\n\u003cli\u003elinks between target behavior and transcriptional or chromatin-state changes\u003c\/li\u003e\n\u003cli\u003esignal-dependent shifts after ligand, inhibitor, or growth-factor perturbation\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for LSD1. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in LSD1 reflect biology rather than handling. When interpreting LSD1, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep LSD1 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577460040025,"sku":"F0438-20UL","price":149.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577460072793,"sku":"F0438-100UL","price":329.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577460105561,"sku":"F0438-2X100UL","price":489.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F0438-IHC1.jpg?v=1773598467","url":"https:\/\/absource.de\/products\/lsd1-antibody-sc-f0438","provider":"Absource Diagnostics","version":"1.0","type":"link"}