{"product_id":"maa-antibody-sc-f3175","title":"Melanoma Associated Antigen 100+ \/ 7 kDa Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eMAA is a target of interest in many antibody-based workflows. Melanoma Associated Antigen 100+ \/ 7 kDa (MAGE) proteins are tumor-associated antigens, typically restricted to germ cells of the testis in normal adult tissues but aberrantly expressed in various cancers, including melanoma, glioma, lung, bladder, and multiple myeloma. The “100+\/7 kDa” designation refers to variants or isoforms with molecular weights around 100 kDa and 7 kDa. Depending on the literature source, MAA may also be discussed as Melanoma Associated Antigen 100+ \/ 7 kDa.\u003c\/p\u003e\u003cp\u003eReported cellular context includes endoplasmic reticulum, endosome, golgi apparatus, and membrane, which can matter when signal is compared across treatments or changing cell states. Following MAA across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eMAA is commonly interpreted in the context of cancer, immunology, and metabolism research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans endoplasmic reticulum, endosome, and golgi apparatus, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between endoplasmic reticulum, endosome, and golgi apparatus across matched conditions\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003econtext differences tied to immune-cell state, activation, or lineage composition\u003c\/li\u003e\n\u003cli\u003eresponses linked to nutrient status, mitochondrial state, or metabolic rewiring\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for MAA. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in MAA reflect biology rather than handling. When interpreting MAA, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep MAA trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57578006610265,"sku":"F3175-20UL","price":199.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57578006643033,"sku":"F3175-100UL","price":489.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57578006675801,"sku":"F3175-2X100UL","price":729.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F3175-IHC1.jpg?v=1773600981","url":"https:\/\/absource.de\/products\/maa-antibody-sc-f3175","provider":"Absource Diagnostics","version":"1.0","type":"link"}