{"product_id":"madecassic-acid-s9502","title":"Madecassic acid","description":"\u003cp\u003e\u003cstrong\u003eMadecassic acid\u003c\/strong\u003e is a natural-product modulator of NF-kB and TNF-alpha and related targets used in studies of JAK-STAT Signaling and NF-kB Signaling and related signaling programs. In practice, this places the compound in experiments that measure cytokine-responsive transcriptional signaling and immune regulation and inflammatory transcriptional control and stress-responsive survival signaling in immunology and inflammation models.\u003c\/p\u003e\n\n\u003cp\u003eBy modulating NF-kB and TNF-alpha and related targets, Madecassic acid can be used to examine cytokine-responsive transcriptional signaling and immune regulation and inflammatory transcriptional control and stress-responsive survival signaling. The immunomodulator annotation adds relevance to immune-cell activation, cytokine, and mediator assays, together with downstream-response mapping in the same experimental setting. In immunology and inflammation models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving NF-kB and TNF-alpha and related targets\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to JAK-STAT Signaling and NF-kB Signaling and related signaling programs\u003c\/li\u003e\n\u003cli\u003eContext-dependent response profiling and mechanism comparison\u003c\/li\u003e\n\u003cli\u003eImmune-cell activation, cytokine, and mediator assays\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Madecassic acid is appropriate when a defined chemical perturbant is needed to connect NF-kB and TNF-alpha and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in immunology and inflammation models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"10 mg","offer_id":57809728700761,"sku":"S9502-10MG","price":95.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57809728733529,"sku":"S9502-100MG","price":488.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/madecassic-acid-chemical-structure-s9502.gif?v=1776205190","url":"https:\/\/absource.de\/products\/madecassic-acid-s9502","provider":"Absource Diagnostics","version":"1.0","type":"link"}