{"product_id":"md2-tlr4-in-1-s0139","title":"MD2-TLR4-IN-1","description":"\u003cp\u003e\u003cstrong\u003eMD2-TLR4-IN-1\u003c\/strong\u003e is an inhibitor of TLR and TNF-alpha and related targets used in studies of JAK-STAT Signaling and NF-kB Signaling and related signaling programs. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to cytokine-responsive transcriptional signaling and immune regulation and inflammatory transcriptional control and stress-responsive survival signaling in immunology and inflammation models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting TLR and TNF-alpha and related targets, MD2-TLR4-IN-1 can be used to examine cytokine-responsive transcriptional signaling and immune regulation and inflammatory transcriptional control and stress-responsive survival signaling. The immunomodulator annotation adds relevance to immune-cell activation, cytokine, and mediator assays, together with downstream-response mapping in the same experimental setting. In immunology and inflammation models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving TLR and TNF-alpha and related targets\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to JAK-STAT Signaling and NF-kB Signaling and related signaling programs\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eImmune-cell activation, cytokine, and mediator assays\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, MD2-TLR4-IN-1 is appropriate when a defined chemical perturbant is needed to connect TLR and TNF-alpha and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in immunology and inflammation models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57805081837913,"sku":"S0139-5MG","price":350.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57805081870681,"sku":"S0139-25MG","price":979.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/s0139-md2-tlr4-in-1-chemical-structure.gif?v=1776171891","url":"https:\/\/absource.de\/products\/md2-tlr4-in-1-s0139","provider":"Absource Diagnostics","version":"1.0","type":"link"}