{"product_id":"met-c-met-antibody-sc-f1043","title":"Phospho-Met\/c-Met (Tyr1349) Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eMET\/C-met is a target of interest in many antibody-based workflows. Gab1 is a type of docking protein that belongs to a group of similar proteins, including IRS, FRS-2\/SNT1, and p62dok. These proteins are substrates of tyrosine kinases and contain an NH2-terminal lipid-binding domain, such as a PH domain or NH2-terminal myristylation sequence, for membrane targeting and a central PTB-like domain for association with specific tyrosine kinases. Depending on the literature source, MET\/C-met may also be discussed as Phospho-Met\/c-Met (Tyr1349) and Phospho Met (Tyr 1349 ).\u003c\/p\u003e\u003cp\u003eReported cellular context includes membrane, cell membrane, and secreted, which can matter when signal is compared across treatments or changing cell states. Following MET\/C-met across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eMET\/C-met is commonly interpreted in the context of cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans membrane, cell membrane, and secreted, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between membrane, cell membrane, and secreted across matched conditions\u003c\/li\u003e\n\u003cli\u003esignal-dependent shifts after ligand, inhibitor, or growth-factor perturbation\u003c\/li\u003e\n\u003cli\u003edifferences between total target abundance and site-specific regulation when modified forms are compared\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for MET\/C-met. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in MET\/C-met reflect biology rather than handling. When interpreting MET\/C-met, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep MET\/C-met trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577596453209,"sku":"F1043-20UL","price":169.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577596485977,"sku":"F1043-100UL","price":379.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577596518745,"sku":"F1043-2X100UL","price":569.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F1043-IHC1.jpg?v=1773599217","url":"https:\/\/absource.de\/products\/met-c-met-antibody-sc-f1043","provider":"Absource Diagnostics","version":"1.0","type":"link"}