{"product_id":"metformin-1-1-dimethylbiguanide-s5958","title":"Metformin (1,1-Dimethylbiguanide)","description":"\u003cp\u003e\u003cstrong\u003eMetformin (1,1-Dimethylbiguanide)\u003c\/strong\u003e is an activator of AMPK and JNK and related targets used in studies of PI3K-Akt-mTOR Signaling and MAPK \/ ERK Signaling and related signaling programs. It is especially relevant in apoptosis, autophagy, and cancer models, where defined compound exposure can be linked to growth-factor signaling, survival control, and nutrient-sensing outputs and mitogenic kinase cascades, proliferation control, and differentiation-linked signaling.\u003c\/p\u003e\n\n\u003cp\u003eBy activating AMPK and JNK and related targets, Metformin (1,1-Dimethylbiguanide) can be used to examine growth-factor signaling, survival control, and nutrient-sensing outputs and mitogenic kinase cascades, proliferation control, and differentiation-linked signaling. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In apoptosis, autophagy, and cancer models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving AMPK and JNK and related targets\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to PI3K-Akt-mTOR Signaling and MAPK \/ ERK Signaling and related signaling programs\u003c\/li\u003e\n\u003cli\u003eGain-of-function pathway-activation studies\u003c\/li\u003e\n\u003cli\u003eBiochemical kinase assays, phospho-signaling studies, and selectivity profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Metformin (1,1-Dimethylbiguanide) is appropriate when a defined chemical perturbant is needed to connect AMPK and JNK and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, autophagy, and cancer models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"25 mg","offer_id":57809311039833,"sku":"S5958-25MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"50 mg","offer_id":57809311072601,"sku":"S5958-50MG","price":242.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57809311105369,"sku":"S5958-1G","price":953.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57809311138137,"sku":"S5958-1ML\/DMSO","price":193.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/s5958-metformin-chemical-structure.gif?v=1776199134","url":"https:\/\/absource.de\/products\/metformin-1-1-dimethylbiguanide-s5958","provider":"Absource Diagnostics","version":"1.0","type":"link"}