{"product_id":"mg132-s2619","title":"MG132","description":"\u003cp\u003e\u003cstrong\u003eMG132\u003c\/strong\u003e is an inhibitor of Proteasome used in studies of Protein Degradation \/ Proteasome. In practice, this places the compound in experiments that measure ubiquitin-dependent turnover, proteostasis, and targeted protein degradation in cancer and protein homeostasis models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting Proteasome, MG132 can be used to examine ubiquitin-dependent turnover, proteostasis, and targeted protein degradation. The protease annotation adds relevance to protease-activity, cleavage, and substrate-processing assays, together with downstream-response mapping in the same experimental setting. In cancer and protein homeostasis models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving Proteasome\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to Protein Degradation \/ Proteasome\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eProtease-activity, cleavage, and substrate-processing assays\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, MG132 is appropriate when a defined chemical perturbant is needed to connect Proteasome with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer and protein homeostasis models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57805682114905,"sku":"S2619-5MG","price":193.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57805682147673,"sku":"S2619-25MG","price":390.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57805682180441,"sku":"S2619-100MG","price":960.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57805682213209,"sku":"S2619-1G","price":2918.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57805682245977,"sku":"S2619-1ML\/DMSO","price":272.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/MG-132-chemical-structure-s2619.gif?v=1776175399","url":"https:\/\/absource.de\/products\/mg132-s2619","provider":"Absource Diagnostics","version":"1.0","type":"link"}