{"product_id":"motixafortide-bl-8040-bkt140-s9665","title":"Motixafortide (BL-8040, BKT140)","description":"\u003cp\u003e\u003cstrong\u003eMotixafortide (BL-8040, BKT140)\u003c\/strong\u003e is an antagonist of CXCR and BCL-2 and related targets used in studies of MAPK \/ ERK Signaling and Immune Signaling and related signaling programs. In practice, this places the compound in experiments that measure mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and cytokine-mediated signaling and inflammatory effector responses in apoptosis, cancer, and cell signaling models.\u003c\/p\u003e\n\n\u003cp\u003eBy blocking CXCR and BCL-2 and related targets, Motixafortide (BL-8040, BKT140) can be used to examine mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and cytokine-mediated signaling and inflammatory effector responses. The gpcr annotation adds relevance to GPCR pharmacology, ligand-binding, and signaling assays, together with downstream-response mapping in the same experimental setting. In apoptosis, cancer, and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving CXCR and BCL-2 and related targets\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to MAPK \/ ERK Signaling and Immune Signaling and related signaling programs\u003c\/li\u003e\n\u003cli\u003eReceptor-blockade and ligand-competition studies\u003c\/li\u003e\n\u003cli\u003eGPCR pharmacology, ligand-binding, and signaling assays\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Motixafortide (BL-8040, BKT140) is appropriate when a defined chemical perturbant is needed to connect CXCR and BCL-2 and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, cancer, and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57809736532313,"sku":"S9665-5MG","price":409.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57809736565081,"sku":"S9665-25MG","price":953.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57809736597849,"sku":"S9665-100MG","price":1936.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57809736630617,"sku":"S9665-1G","price":4904.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/s9665-motixafortide-bl-8040--chemical-structure.gif?v=1776205207","url":"https:\/\/absource.de\/products\/motixafortide-bl-8040-bkt140-s9665","provider":"Absource Diagnostics","version":"1.0","type":"link"}