{"product_id":"mubritinib-tak-165-s2216","title":"Mubritinib (TAK 165)","description":"\u003cp\u003e\u003cstrong\u003eMubritinib (TAK 165)\u003c\/strong\u003e is an inhibitor of HER2 used in studies of PI3K-Akt-mTOR Signaling and MAPK \/ ERK Signaling. In practice, this places the compound in experiments that measure growth-factor signaling, survival control, and nutrient-sensing outputs and mitogenic kinase cascades, proliferation control, and differentiation-linked signaling in cancer and cell signaling models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting HER2, Mubritinib (TAK 165) can be used to examine growth-factor signaling, survival control, and nutrient-sensing outputs and mitogenic kinase cascades, proliferation control, and differentiation-linked signaling. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In cancer and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving HER2\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to PI3K-Akt-mTOR Signaling and MAPK \/ ERK Signaling\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eBiochemical kinase assays, phospho-signaling studies, and selectivity profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Mubritinib (TAK 165) is appropriate when a defined chemical perturbant is needed to connect HER2 with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"10 mg","offer_id":57805468008793,"sku":"S2216-10MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57805468041561,"sku":"S2216-25MG","price":242.0,"currency_code":"EUR","in_stock":true},{"title":"200 mg","offer_id":57805468074329,"sku":"S2216-200MG","price":855.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57805468107097,"sku":"S2216-1ML\/DMSO","price":193.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/Mubritinib-TAK-165-chemical-structure-S2216.gif?v=1776174650","url":"https:\/\/absource.de\/products\/mubritinib-tak-165-s2216","provider":"Absource Diagnostics","version":"1.0","type":"link"}