{"product_id":"muc16-antibody-sc-f3453","title":"MUC16 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eMUC16 (Mucin 16) is the largest known type I transmembrane mucin, originally identified as carbohydrate antigen 125 (CA125), a classic ovarian cancer biomarker. Encoded on chromosome 19p13. 2 and comprising 22,152 amino acids, MUC16 has a massive molecular weight and consists of three main domains: an N-terminal extracellular region rich in O-glycosylation, a large tandem repeat domain containing 16 SEA (sea urchin sperm protein, enterokinase, agrin) modules, and a C-terminal domain with an extracellular segment, a transmembrane region, and a short cytoplasmic tail featuring an NLS, ERM-binding site, and phosphorylated tyrosine. Depending on the literature source, MUC16 may also be discussed as CA125 and Mucin-16.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cell membrane, membrane, and secreted, which can matter when signal is compared across treatments or changing cell states. Following MUC16 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eMUC16 is commonly interpreted in the context of cancer, immunology, and metabolism research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cell membrane, membrane, and secreted, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cell membrane, membrane, and secreted across matched conditions\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003econtext differences tied to immune-cell state, activation, or lineage composition\u003c\/li\u003e\n\u003cli\u003eresponses linked to nutrient status, mitochondrial state, or metabolic rewiring\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for MUC16. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in MUC16 reflect biology rather than handling. When interpreting MUC16, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep MUC16 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57578024534361,"sku":"F3453-20UL","price":169.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57578024567129,"sku":"F3453-100UL","price":369.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57578024599897,"sku":"F3453-2X100UL","price":549.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F3453-IHC1.jpg?v=1773601232","url":"https:\/\/absource.de\/products\/muc16-antibody-sc-f3453","provider":"Absource Diagnostics","version":"1.0","type":"link"}